Summer, 1953. In the small town of Gravesend, New Hampshire, eleven-year-old John Wheelwright and his best friend Owen Meany are playing in a Little League baseball game.
When Owen hits a foul ball which kills John's mother, their lives are changed in an instant. It is dismissed as a tragic accident but Owen disagrees. He believes that he is God's instrument, put on Earth for a higher purpose.
And as the boys come into adulthood to the background of the Vietnam War, a series of remarkable events show that perhaps Owen's divine plan was not imagined after all.